2013年1月14日，清华大学科学生命院教授陈晔光博士应邀访问购宝钱包 并举办学术讲座。讲座的题目为：c-Cbl stabilizes the TGF-β type II receptor via neddylation。王晓晨博士主持讲座。

Abstract:  

Transforming growth factor β (TGF-β) is a potent anti-proliferative factor in multiple types of 购宝钱包 s.  Deregulation of TGF-β signaling is associated with development of many cancers including leukemia while the molecular mechanisms are largely unclear.  We show that c-Cbl, a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII).  Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem/progenitor 购宝钱包 s to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia 购宝钱包 s to TGF-β.  c-Cbl conjugates NEDD8, a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while prevents its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation.  We have also identified a neddylation activity-defective c-Cbl mutation from leukemia patients, implying the link between aberrant TβRII neddylation and leukemia development.